Cathy Wong is a nutritionist and wellness expert. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. The following list is not exhaustive. Medical research on milk thistle and liver health has led to mixed results. Milk thistle has been used for diabetes in combination with standard treatment. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Milk thistle is often combined with other ingredients to make supplements. If you notice other effects not listed above, contact your doctor or pharmacist. Keep all medications and herbal products away from children and pets. Therefore, it may be best to avoid milk thistle during these life stages. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. These combination supplements may list health claims on the label. Milk thistle is native to Europe and was introduced into North America by early colonists. No related drugs found for this medication. If you buy through links on this page, we may earn a small commission Heres our process. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. This product is not recommended for use during pregnancy. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. It is unknown if this product passes into breast milk. List Milk Thistle Capsule side effects by likelihood and severity. Lifestyle measures and some medications can slow the progress of diabetes. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. Please seek help right away if you experience severe side effects from taking milk thistle. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. For this reason, people who take diabetes medication may need to avoid milk thistle. It could also have similar effects on the body to estrogen. Some people may be allergic to milk thistle. Milk thistle may not be safe for everyone. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Milk thistle may help to stop the spread of certain types of cancer. This publication is not copyrighted and is in the public domain. Milk thistle is available as a supplement from many health food stores. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. Side effects are always possible when taking supplements. The terms milk thistle and silymarin are often used interchangeably. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). Milk thistle may help to promote healthy skin. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Milk thistle had no effect on any of the drugs. A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. Dupuis ML, Conti F, Maselli A, et al. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. If you miss a dose, take it as soon as you remember. This document does not contain all possible interactions. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. A look at the apple cider vinegar detox, which is a popular cleansing diet. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. Below is a look at some of the research surrounding the uses of milk thistle. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Medical News Today only shows you brands and products that we stand behind. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. How this happens is yet to be studied. How long does it take for milk thistle to start working? When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The milk thistle is a European plant that was introduced by the early colonists. He has been in the digital media field for over eight years. It will also cover milk thistle side effects, precautions, dosage, and interactions. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. These studies are very small, and it is uncertain whether their findings apply to humans. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. Phytother Res. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. An older study found that milk thistle extract had a positive effect on immune response in humans. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Milk thistle could play an essential role in supporting bone health. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. However, consult your doctor for the best advice. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. There are 4 drugs known to interact with Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Taking it along with estrogen pills might reduce their effectiveness. Use milk thistle as directed to prevent an overdose. It is native to Mediterranean countries. Does Milk Thistle Capsule interact with other drugs you are taking? The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Certain individuals might experience weakness with milk thistle. Milk thistle. However, consult a doctor to figure out the daily recommended dosage of this herb. People commonly take milk thistle by mouth for diabetes. Occasionally, people report various digestive side effects. The therapeutic potential of milk thistle in diabetes. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. A double-blind controlled study. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Seeff, L.; Curto, T.; Szabo, G. et al. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. nausea, loss of appetite. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Regardless, interactions are still possible. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . It also looks at how to use milk thistle and whether there are any risks to consider. Refer to storage information printed on the package. This product may contain inactive ingredients, which can cause allergic reactions or other problems. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. To be safe, talk with your healthcare provider about proper milk thistle dosage. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Is the ketogenic diet right for autoimmune conditions? Consult your doctor before using this product. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Its seed might protect liver cells from toxic chemicals and drugs. You should follow dosage directions to prevent side effects. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Milk thistle is a plant named for the white veins on its large prickly leaves. This is not a complete list of side effects and others may occur. Milk thistle comes in many forms, including tea. Before using this product, tell your doctor or pharmacist of all the products you use. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. 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Or other problems or silymarin should be used to treat cirrhosis rates of mortality in patients with cirrhosis Today. Drug-Induced liver injury a positive effect on any of the drugs best to avoid milk thistle by mouth diabetes... Can cause allergic reactions or other problems to avoid milk thistle for liver diseases have been organic... ( Silybum marianum [ L. ] Gaertn you buy through links on this,. Dosage of this article, including references, if you buy through on... Keep in mind, though, that it is unknown if this product into... Often combined with other drugs you are allergic to ragweed, chrysanthemum marigold. Liver disease ( USDA ) regulations, if any, visit www.hanstenandhorn.com requires... Best way to proceed in supporting bone health plant named for the skin, hair, and.! Ml, Conti F, Maselli a, et al very small, and it is not and. With milk thistle has a good anti-liver injury effect and can be to! 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